Exact(2)
Alternative splicing (AS) has been regarded capable of altering selection pressure on protein subsequences.
Furthermore, there were no effects of altering selection criteria on burst firing analysis: the proportion of bursting neurons increased from 26% in controls to 57% in T GPs, and the burst rate of runs increased from 0.02 ± 0.002 bursts/s in controls to 0.07 ± 0.02 bursts/s in T GPs (P < 0.05).
Similar(6)
Anthropogenic habitat alteration creates novel environments that can alter selection pressures.
Hatchery fish experience altered selection pressures i.e. high juvenile density and abundance of food may select for behavioral and physiological traits that are disadvantageous in natural conditions [ 6].
Global environmental change is expected to alter selection pressures in many biological systems1,2,3, but the long-term molecular and life history data required to quantify changes in selection are rare4.
The outcome should leave Sir Alex Ferguson in discomfort since the much altered selection he fielded proved not at all equipped for the task.
We conclude that the TI-2 antigen-induced altered selection of TD Ag-inducible clones and its severe gene-specific influence on further somatic mutations and affinity maturation represents a network memory, which we hypothesize to be mediated by anti-idiotypic regulatory T cells.
Consequently, variation in the age-trajectories of survival and fertility among populations do not greatly alter selection on alleles involved in susceptibility to late-onset diseases (in agreement with results from [3]), unless such changes alter the effective population size.
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