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High ROS levels can damage cells by peroxidizing lipids, disrupting DNA, modulating gene transcription, altering proteins, and resulting in decline of physiological function and cell apoptosis/death [ 40].
High ROS levels can damage cells by peroxidizing lipids, disrupting DNA, modulating gene transcription, altering proteins, and resulting in a decline in physiological function and cell apoptosis/death.
A major increase in ROS is detrimental to muscle cells due to cytotoxicity and can impact cells by damaging or altering proteins and membrane lipids, thus altering cellular integrity [ 54].
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Kinases are enzymes that alter proteins and lipids by phosphorylation, the addition of a phosphate group.
Moreover, it has been proposed that oxidative stress also alters proteins, and this seems to be another explanation for decreased signalling molecule activation and activity.
Many functional analyses of SNPs have examined coding regions and splicing sites in candidate genes related to wood traits that can alter proteins and mRNA splicing.
However, dramatic increases in ROS result in significant damage to human cells by altering proteins, lipids and DNA.
In contrast, phenolic compounds might reduce the quality of sunflower proteins by inhibiting digestibility, causing undesirable browning and structural modifications, and altering protein functional properties and behavior in various food matrixes.
A titre of 107 T.U./ml was effective in altering protein expression and such manipulations correlated with changes in cell proliferation.
This again supports the finding that EspG alters cell surface receptors by inhibiting the function of recycling endosomes rather than altering protein synthesis and transport.
Furthermore, sequencing of the c-Met gene demonstrated that acquired resistance to SU11274 was not associated with mutations altering protein structure and activity.
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