Sentence examples for altering protein function from inspiring English sources

The identification of new chemical entities that are capable of altering protein function lies at the heart of the hit and lead finding process, for which combinatorial chemistry has emerged as a powerful tool.

4HNE has a high affinity towards cysteine, histidine and lysine residues forming direct protein-adducts and thereby altering protein function.

In summary, heterologous PEDF expression is greatly improved by using codons that match those preferred by the host translational system without altering protein function.

AGEs tend to affect cellular function by altering protein function (11).

So, it is very likely that there are unreported nsSNPs increasing disease predisposition by altering protein function or structure.

Elevated tHcy levels promote the homocysteinylation of proteins, thus altering protein function [ 58, 59], and inhibit Na+/K+-ATPase activity [ 60].

The amino acid residues directly altering protein functions were inferred according to the locations of substitutions on the functional sites of protein structures.

Small molecules altering protein functions as inhibitors, agonists or antagonists, find application in systems biology enabling an analysis of the in vivo consequences of these alterations.

Because underlying biological vulnerabilities are critical for many diseases, databases determining associated genetic polymorphisms (Pearson-Fuhrhop et al., 2009) might facilitate the development of therapies aimed at altering protein functions to regulate neuroplasticity.

The finding of a functional variant, which alters protein function, would greatly enhance our understanding of the mechanisms of albumin excretion in kidney health and disease.

Nevertheless, mutational studies on at least five different proteins with conserved codon repeats have demonstrated that alteration in amino acid repeat length alters protein function [ 29, 56].