The phrase "altering of the initial" is correct and usable in written English.
It can be used when discussing changes made to an original element or starting point in a process or context.
Example: "The altering of the initial design was necessary to meet the new requirements set by the client."
Alternatives: "modification of the original" or "change to the initial".
However, through a combination of decreasing subsequent cleavage processivity, altering the site of the initial ε-cleavage to favor the Aβ42 product line, or some combination, these effects can increase the relative level of production of Aβ42.
Optimization of the palindrome did not significantly alter the binding of the initial TtgR dimer to the operator, but increased the cooperativity of binding and consequently the overall affinity.
The fingers-domain insertion induced changes in the shape of the β3-β4 loops that could alter the position of the initial binding site of dNTP and NRTI relative to the catalytic site.
We performed propensity matching to identify comparator DM and non-DM groups that were similar in age, sex, and CAD risk factors but, in doing so, altered the makeup of the initial overall study group.
At each step, the variables were entered individually in order of the magnitude of their zero-order correlations with IQ and retained in the model only if their entry altered the relation of the initial contaminant to IQ (standardized regression coefficient β) by at least 10% (Greenland and Rothman 1998).
Informational modifiers (such as suppressors of nonsense mutations in classical screens [e.g., Hodgkin et al., 1989], and modifiers of germline RNAi sensitivity in this experiment) alter the effect of the initial perturbation in a non-gene-specific manner, while gene-specific modifiers reveal functional features of the targeted locus.
The addition of student responses (n = 214) from a CU Molecular Cellular and Developmental Biology (MCDB) introductory biology course into the data set did not alter the results of the initial factor analysis (unpublished data), so only EBIO student data were used for the analyses.
The altered binding of the pterin due to mutagenesis of Glu332 alters the initial reaction of the enzyme with oxygen, resulting in direct oxidation of the tetrahydropterin, or the mutation prevents the heterolytic cleavage of the oxygen oxygen bond in the initial intermediate.
γ-Secretase modulators (GSMs) are small molecules that lower Aβ42 levels by altering γ-secretase processivity without significantly altering the initial ε-cleavage of APP.
The morphology and size of the NaLa(MoO4 2 particles can be tuned in a controlled manner by altering the pH value of the initial solution, reaction temperature, and composition of solvent.
