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This article introduces a new method for generating benchmarks that is based on structural modifications of a user-specified design without altering its function.
Our study was aimed at elucidating whether the c.501G>C polymorphism changes the binding affinity of LOX-1 receptor altering its function.
No significant difference was observed between any of the sterilization methods and the control condition after 32 cycles, demonstrating that the device can be sterilized without altering its function as shown in figure 5.
Computational modeling suggests that A578S should considerably affect the tertiary structure of the K13 protein, thereby destabilizing the domain scaffold and altering its function (15 ).
Since the cytoskeleton plays such a crucial role in controlling cell motility [ 119], altering its function through lncRNA binding may emerge as a frequent molecular event underlying cancer metastasis.
Monorden, also known as radicicol, was a natural product binding to Hsp90 (Heat Shock Protein 90) and altering its function, while Hsp90 acted as a regulator of pathogenic changes that leaded to the neurodegenerative phenotype in AD [ 45].
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Plausibly, a slight change in choice of molecules results in a significantly dissimilar analog of a drug while not altering its functioning on many targets.
These results are a proof of principle that improving the performance of an OLED by a non-lithographic surface modification strategy and without altering its functioning, is feasible.
Even though the overall structural organization of the p110β RBD is conserved (Zhang et al., 2011), we speculated that because we cannot detect any interaction with RAS, it might have lost or altered its function.
Although the role of Notch3 in the development of age-related cerebral small vessel disease can easily be envisioned, it remains speculative how the described mutations alter its function.
Now drugs can be developed for every protein to alter its function and help clear up a malfunction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com