The phrase "altering its ability to" is correct and usable in written English.
It can be used when discussing changes that affect someone's or something's capacity to perform a function or task.
Example: "The new policy is altering its ability to respond quickly to customer inquiries."
Alternatives: "changing its capacity to" or "modifying its capability to".
Speculation exists that BRCA1 phosphorylation may affect its cellular localization and stability as well as altering its ability to bind other proteins and thus, affect its biochemical activities as they are related to DNA damage repair or gene transcription [16].
The co-incubation of DCs with LP and Salmonella significantly reduced the ability of Salmonella to induce IL-12p70 and TNF-α, while not altering its ability to promote IL-10 and IL-6 production (Fig. 5).
In contrast, the regulation and specificity of c-Myb appears to be regulated during the cell cycle and may be linked to its interactions with Cyclin D1/CDK complexes, since phosphorylation at specific residues could change the affinity of c-Myb for promoters by altering its ability to interact in a combinatorial fashion with other proteins [37].
P140 directly impairs the molecular chaperoning properties of HSC70 by altering its ability to promote proper folding of polypeptide.
Another option is to decrease the ability of the protein to reach the site of toxicity by altering its ability to translocate between the nucleus and cytoplasm.
This has clear effects on cell trafficking events in mpkCCD cells, which are mimicked by RNAi knock-down of PI5P4Kγ, and either this is because it is inhibiting the PI5P 4-kinase activity of PI5P4Kγ, or it is displacing the enzyme from its localization in intracellular vesicles and thus altering its ability to target other proteins to these vesicles.
These data demonstrated that although the T198A mutation increased the ability of p27 to bind the CDK2 containing complexes it did not alter its ability to inhibit the kinase activity and that the effects observed with the T198A mutation cannot be related to the lack of T198 phosphorylation since the T198V and T198D mutants displayed an activity similar to that of the WT protein.
All PCa-associated SPOP mutations discovered thus far affect evolutionarily conserved residues within the MATH domain and alter its ability to bind substrates8,9,10.
Hoping to improve the action of factor VII, biochemist Gary Nelsestuen of the University of Minnesota, St . Paul and his colleagues tried to alter its ability to bind to membranes, a critical step in starting a clot.
Using immunoprecipitation (IP) assay, we found that phosphorylation of Hand1 did not alter its ability to bind E12 (Figure 5A).
Loss of basic charge caused by citrullination is thought to disrupt charge distribution within the substrate protein and alter its ability to interact with other molecules [1], [2].
