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Although our experiments and those of others (Gemberling et al., 2013; Poss et al., 2003) show that the regenerative capacity of zebrafish is vulnerable to single gene alterations, whether altering function of a single gene in mammals would induce the emergence of robust epimorphic regenerative capacity is a much more complex issue.
Small fluorescent groups can act as "tags" or probes -- can be attached to larger molecules such as antibodies, usually to one end, often without altering function of macromolecule.
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We first evaluated whether MWCNT 1 promoted myogenic differentiation by altering functions of these two families of proteins or their interactions.
Moreover, functional assays using Saccharomyces cerevisiae revealed that the Y424H substitution did not alter function of CHEK2 protein.
Therefore, altered function of OPC processes following Nf1 loss may have substantial effects on their cellular activities.
Although dimethyl sulfoxide (Me2SO) is generally regarded as a safe cryoprotectant, even low levels may alter function of repopulating cells.
Nonsense or frameshift mutations were relatively rare, given that TP53 is a tumor suppressor gene, and the predominance of missense mutations may indicate altered function of TP53 rather than complete inactivation.
This may be an essential factor in the triggering of attacks or may reflect generally altered function of central autonomic command.
Therefore, altered function of the limbic system appears to produce psychiatric disorders as well as osmophobia, and finally can provoke suicidality.
As a consequence, altered function of the aPFC could have important ramifications for decision-making capability in drug abusers.
Our findings emphasize that mutations which alter function of the MAPK pathway play an important role in ovarian cancer [15].
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