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We further found the potentially altered cell adhesion and angiogenesis properties in the CML state when compared to the normal group.
It has been known for a number of years that microtopography can alter cell adhesion, proliferation and gene expression.
Sb supernatant did not alter cell adhesion to laminin-111.
However, the ECM can also alter cell adhesion, migration, proliferation/survival, and differentiation.
Mitostatin altered the cell adhesion properties to laminin, which is the first necessary step to invade the Matrigel membrane.
However, it is possible that target cell transfection and treatment with TGFβ1 altered T cell adhesion properties by some alternative mechanism.
Cells anchored in a three-dimensional (3-D) microenvironment show significantly altered phenotypes, from altered cell adhesions, to cell migration and differentiation.
Sui, X. et al. Stability and cell adhesion properties of poly N-isopropylacrylamide) brushes with variable grafting densities.
UCH L1 is associated with enhanced proliferation and decreased cell adhesion properties [21].
Therefore, it seems possible that Cul-5 CRLs impact on cell adhesion properties through an effect on EGFR signalling, or on downstream cell adhesion molecules or their regulators.
Blocking β1 also reduced tumour cell adhesion properties.
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