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Consumption of crude khat extract or its alkaloid fraction preceding stress has been shown to produce oxidative stress in rats by altering activities of serum antioxidant enzymes [ 6].
These small molecules act (i) directly, following their delivery to the mitochondrial matrix, the IMM or the OMM; or (ii) indirectly, by binding to and altering activities of transcription factors for nuclear genes encoding various mitochondrial proteins [ 34, 53- 61].
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To evaluate the effects of altered IIS on growth rate and the timing of metamorphosis, we began by altering activity of genes of the protein kinase A (PKA) pathway within the insulin producing cells (IPCs).
Although inhibition of calcineurin results in immunosuppression, altering activity of NFAT will also impact regulation of INS1 gene transcription.
Significant associations represent variants that may have a direct effect on the transcription rate of nearby genes, likely by altering activity of cis-regulatory elements.
Polymorphisms in the GST genes, such as GSPT1 (rs1695), affect the ability to respond to excessive oxidative stress by altering activity of the GST enzymes [ 45].
Accumulating evidence demonstrates altered activities of orexin neurons in response to feeding-associated behaviors in both appetitive40,43 and consummatory aspects15,44.
This study was designed to evaluate the preventive effects of zingerone (vanillyl acetone) on tachycardia, LVH, altered electrocardiogram (ECG), altered activities of membrane bound ATPases, electrolyte imbalance and myocardial infarct size in isoproterenol induced myocardial infarcted rats.
First, we noticed altered activities of Slitrk6-KO mice in the home cage (Fig. 3).
The transgenic mice (mutPOLG Tg mice) harbor mtDNA defects in the brains, which show altered activities of serotonin and noradrenalin.
Furthermore, TRF2 can alter activities of various DNA metabolic/repair enzymes and the ability of TRF2 to stimulate or inhibit certain activities depends on the nature of the substrate [44], [69], [74], [75], [76].
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