Sentence examples for altered trail from inspiring English sources

Second, our primary selection of genes whose LOF altered TRAIL activity was based on caspase-3/7 activation 1 hour after the addition of TRAIL, whereas the previous study measured viability 20 hours after the addition of TRAIL.

Intriguingly, only the CD8+ T cell associated DR4, DcR1 and DcR2 expression levels correlated with DAS28 scores in patients with RA, implying that altered TRAIL receptor profiles on CD8+ T cell subsets rather than on CD4+ T cells is more important in terms of disease severity.

Consequently, diseases caused by each of these viruses are thought to be mediated, in part, by altered TRAIL: TRAIL receptor interactions.

Transfecting Huh7 cells with siRNA for JNK I, JNK II, or p38 did not intrinsically alter TRAIL R2 levels (Figure 4B).

In addition, similar knockdown of OPG levels in MCF-7 breast cancer cells did not alter TRAIL sensitivity 25.

However, inhibition of c-Jun with a dominant-negative construct failed to alter TRAIL sensitivity (data not shown), indicating that c-Jun does not have a major role in regulating c-FLIP expression.

However, treatment of HeLa or A549 cells with PIK-75 or SNS-032 did not alter TRAIL-R1/R2 surface expression, in line with similar recruitment of TRAIL-R1/2 in the DISC analysis.

Unlike HSP90 α/β, silencing of RIP1 was unable to alter TRAIL-induced cell death during HS (Supplementary Figure 3d), suggesting that HSP90's regulatory properties are independent of RIP1.

We therefore tested whether HIV particles or HIV proteins altered either TRAIL receptor expression or TRAIL sensitivity of the human hepatocyte cells, Huh7.

Therefore, PBLs from the 6 HIV-infected individuals were cultured with 5 ng/mL of TRAIL or BSA to determine if TRAIL altered T cell, B cell, or NK cells numbers, or CD4+ and CD8+ T-cell function.

Nevertheless, this unique BNIP3 repressor function for DR5 gene alters TRAIL-induced apoptosis in glioma cells and could be an important mechanism for TRAIL resistance in GBM tumors.