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Indeed, aging-related, cell autonomous changes have also been shown to contribute to altered HSC function [ 28, 36- 38].
The defects appear to be related to altered ameloblast function during the transitional and maturation phases.
These items seem to reflect altered cognitive function possibly due to decreased concentration and speed of response.
Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation.
Bendsten et al. [28] found qualitatively altered stimulus response function to supra-threshold pressure pain stimulation in CTH sufferers.
As yet, the pathological mechanisms connecting mutant Rab7 protein expression to altered neuronal function are undefined.
At this stage, however, the primary mechanisms linking Dp71 loss to altered synaptic function remain uncertain.
Therefore, silent SNPs that do not change the coding sequence of the protein may contribute to altered gene function.
Likewise, changes in gene expression observed in the Δstp1 and Δstk1 strains could also be attributed to altered HU function.
Phosphorylation of Bax at several residues has been linked to altered apoptotic function including altered mitochondrial translocation.
These studies show that enhanced SP innervation in human airway sensory nerves may contribute to altered airway function.
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