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This has been witnessed in several experimental and computational studies [10], [11], [12], [13], [14], [15], [16], where removal of Ca2+ from the binding sites of Calmodulin (CaM) significantly altered the stability of the protein.
We next tested whether 15-LOX-1 altered the stability of HIF-1 α under hypoxia.
Data generated using the ProtScale and PyMOL programs revealed that the mutation altered the stability and solubility of the αB-crystallin protein.
Neither caspase inhibitors nor calpain inhibitors altered the stability of ER α under untreated and TNF α-treated conditions (data not shown).
To validate the involvement of AUF1 isoforms in the destabilization of DNMT1 mRNA, we examined whether AUF1 altered the stability of DNMT1 mRNA.
Indeed, withanolide E treatment altered the stability of a number of HSP90 client proteins, but with greater apparent specificity than the well-known HSP90 inhibitor geldanamycin.
Similar(52)
The substituted proteins (UbldG12R, UbldV15M, UbldD18N, UbldK32T, UbldR33Q, UbldQ34R, UbldP37L, UbldK48A) that exhibited a folded structure were examined to determine if the substitutions had altered the stabilities of the proteins.
Changes in water temperature may alter the stability of gas hydrates.
Specifically, the system would alter the stability margin when parameters vary.
The results show that the semi-vertex angle and CNT distribution may alter the stability boundaries.
It is possible to consider only its homogeneous part in that inhomogeneous terms do not alter the stability properties.
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