The phrase "altered the specificity of" is correct and usable in written English.
It can be used when discussing changes made to the precision or detail of a particular subject or concept.
Example: "The new research findings altered the specificity of the original hypothesis, leading to a more nuanced understanding of the phenomenon."
Alternatives: "changed the precision of" or "modified the detail of".
Modification in the structure of SAHA altered the specificity of 'δ ' towards a specific HDAC enzyme[83].
A PBP added to an in vitro assay altered the specificity of a moth pheromone receptor, making its response more specific [31].
Thus, the levQE170A/F292S mutations altered the specificity of the signaling complex independently of LevT.
Previous work successfully altered the specificity of MjTyrRS toward unAAs by focusing on changing the enzyme's amino acid recognition pocket.
Therefore, we measured the contribution of fHbp residues to interactions with CFHR3 to determine whether any amino acid changes altered the specificity of fHbp for the two complement factors.
Subsequent gene duplication of this first tRNAGly, with mutation of nucleotides comprising the operational RNA code in the acceptor stem of one of the copies, would have altered the specificity of aminoacylation by the RNA synthetase, for example from glycine to serine.
The flexibility of the described design allows for sensor specificity change through altering the specificity of the aptamer.
Altering the specificity of DNA-cleaving enzymes could be useful in many medical or biotechnological applications, but it is quite a challenge in terms of computational protein design.
I am also using a cell-based functional assay to test whether I can alter the specificity of particular types of clustered protocadherins by introducing mutations into the interaction interface.
A second series of reporters, activated by human rhinovirus 3C protease, demonstrated that we could alter the specificity of the reporter by reengineering the protease recognition sequence.
Furthermore, in the context of Cdc4alpha and cyclin E, mutational data suggest that Pin1 isomerizes a noncanonical proline-proline bond, with the possibility that Cdc4alpha may serve as a cofactor for altering the specificity of Pin1.
