Sentence examples for altered the localization of from inspiring English sources

Second, previous studies raised concerns that AID fusion can destabilize substrate proteins4, and we observed that fusing mAID to Venus or Venus-ANAPC4 partially altered the localization of the fusion protein.

Downregulation of Arf1 expression by small interfering RNA (siRNA) decreased both the levels of HCV RNA and the production of infectious viral particles and altered the localization of NS5A to the peripheries of LDs.

Thus, we determined how stress and pharmacological kinase inhibitors altered the localization of transport components.

This relatively late lethal stage allowed us to determine whether the loss of Lamin C altered the localization of other nuclear proteins.

Dot1L partially colocalized with both CALM-AF10 and NES2-AF10, but neither CALM-AF10 nor NES2-AF10 altheed the localization of Dot1L (Fig. 5a).

Intriguingly, the Phe216Ala substitution markedly altered the localization of TSC1; Phe216Ala was exclusively cytoplasmic and diffuse in full growth medium and did not redistribute to discrete bodies in amino acid deficient conditions (Fig.  6).

In contrast to the observation of Myo3A/espin 1 in filopodia, Myo3A does not alter the localization of espin 1 in microvilli, and espin 1 localized throughout the microvilli, although the kinase dead Myo3A was localized at the tip of microvilli.

These results indicate that aging could be altering the localization of the NR2B subunit to the synaptic membrane within the frontal cortex.

The present experiments were designed to test the hypothesis that CD might function as a pro-apoptotic trigger by altering the localization of connexin 43 gap junction protein and gap junctional intercellular communication (GJIC).

By contrast, co-expression of Gn was sufficient to alter the localization of RdRp (Fig. 3B).

Our data demonstrate that the absence of MSH3 does not alter the localization of MSH2 (Figure S5).