"altered targets" is a perfectly grammatical and usable phrase in written English.
For example, you could write, "The company adjusted its sales targets after the rush of holiday shopping."
These novel, ultra-rare variants in the mature miRNAs were predicted to have altered target specificity and perhaps new endogenous targets.
To determine whether a change in LARK abundance altered target RNA levels, we queried whole genome microarrays with total RNA samples from elav-gal4/+; UAS-lark/+ flies (pan-neuronally overexpressing LARK) and elav-gal4/+; +/+ (control) flies, respectively.
Bacteria may adopt various strategies to enhance the resistance to antibiotics, including the following: efflux pumps that can remove therapeutic levels of antibiotics; drug degradation or modification; reduced membrane permeability; altered target sites or metabolic pathway (reviewed by [21]).
Similarly, the mutation could somehow lead to altered targeting of Beclin 1-binding proteins to the endoplasmic reticulum (ER).
Qualitative (type of target gene) and quantitative (number and frequency of altered target genes) differences have been observed regarding MSI-H target genes in different types of cancers.
Next we investigated expression of known targets of one abdominal Hox protein to confirm that altered target gene expression correlates with specific homeotic phenotypes.
Nucleotide variations to the reference miRNA transcript sequence may have altered target specificity and thereby modulate different biological processes to further fine tune post-transcriptional gene expression.
Only those candidate DUB genes, exhibiting significantly altered target expression when knocked down by RNAi, were chosen as potential Notch regulators.
However, the potential limitations for such an experimental approach is the overexpression of miRNAs to non-physiological levels that may lead to altered target genes.
