The phrase "altered target" is correct and usable in written English.
It can be used in contexts where a target or goal has been modified or changed in some way.
Example: "The research team had to adjust their approach due to the altered target set by the funding agency."
Alternatives: "modified target" or "changed target".
Genomic analysis of the patients' samples has become possible which may provide a rapid indication of altered target molecules.
A redesigned enzyme that was predicted to display altered target site specificity, while maintaining wild-type binding affinity, was experimentally characterized.
While the latter insertion is in a bulge in the inferred secondary structure of the miRNA that is unlikely to affect folding or putative targets, the substitution in mir-1304 occurs in the seed region, suggesting that it is likely to have altered target specificity in modern humans relative to Neandertals and other apes (fig. S16).
These novel, ultra-rare variants in the mature miRNAs were predicted to have altered target specificity and perhaps new endogenous targets.
To determine whether a change in LARK abundance altered target RNA levels, we queried whole genome microarrays with total RNA samples from elav-gal4/+; UAS-lark/+ flies (pan-neuronally overexpressing LARK) and elav-gal4/+; +/+ (control) flies, respectively.
Bacteria may adopt various strategies to enhance the resistance to antibiotics, including the following: efflux pumps that can remove therapeutic levels of antibiotics; drug degradation or modification; reduced membrane permeability; altered target sites or metabolic pathway (reviewed by [21]).
Introduction and accumulation of substitution mutations into a duplicated EPIYA segment may then endow altered target-binding specificities, which could generate functional diversification of bacterial EPIYA effectors (Fig. 2B).
Integrated analyses examining microRNA-mRNA interactions suggested multiple altered targets within the Notch signaling pathway.
Similarly, the mutation could somehow lead to altered targeting of Beclin 1-binding proteins to the endoplasmic reticulum (ER).
For instance, recent studies suggest that directed methylation can alter target gene expression, although methylation is rapidly lost upon removal of the dCas9-effector12,13,17.
Immunizing drives could block the spread of unwanted gene drives by preemptively altering target sequences.
