Using isolated recombinant human iPLA2γ, both Cys233Ser and Cys329Ser targeted mutations revealed altered regulation of the catalytic activity by H2O2.
Crt−/− T cells have an altered regulation of calcium signalling resulting in hyper responsiveness to TCR stimulation.
This would be entirely consistent with the hypothesized altered regulation of plant defence during rhizobial invasion of lin [86].
Finally, pathway analysis suggests that altered regulation of transcription may underlie decreased variance and may increase risk for autism.
This altered regulation of chemokine and chemokine receptor expression correlates with the preferential reduction in infection of CD4+ T lymphocytes with an R5 versus X4 virus isolate.
Extracellular stimulants induce various cellular responses by regulating diverse pathways, and perturbation of any genes in the pathway can generate altered regulation of signaling networks.
However, the rate of cholesterol efflux from the LE/LY is severely impaired [30], [31], [32], resulting in altered regulation of cholesterol homeostasis [20], [23], [33].
Angiogenin is functionally similar to vascular endothelial growth factor (VEGF), altered regulation of which has also been associated with ALS [5], [6].
Indeed, adhesion pathways and their altered regulation by B-catenin and Wnt signaling are important in the progression of thyroid tumors [6].
Even proteins with homologs of known function may have a different biological role due to altered regulation, posttranslational modification, or cellular compartmentalization [4], [5].
However, pathways linked to gene expression and the cell cycle displayed altered regulation.
