Since BicD levels are important for overall function, one possibility was that the point mutation altered protein expression or stability.
In other words, altered protein expression by recipient cells could be an ongoing translation of these mRNAs.
Cells that are in a state of oxidative stress are more likely to have altered protein expression.
IHC was performed to investigate altered protein expression in 430 human breast cancer tissues and 4 normal breast tissues.
This suggests that at 12 h post-rWNT5A stimulation in A2058 cells, altered protein expression levels of key mediators are required for changes to cell adhesion.
Besides, altered protein expression profiles in body fluids reflect the change of physiological states and cellular networks of the diseased tissue/organ.
We further compared altered protein expression in astrocytes at the late stage of chEAE and at the remitting stage of remitting-relapsing EAE (rrEAE).
Gene expression data may then be mined not only for evidence of the mechanics of genetic regulatory pathways but also for evidence of shifts in extracellular signaling, which cause altered protein expression.
Cancers showing a noteworthy overlapping of genome mutations, transcriptome dysregulation and altered protein expression were pancreatic tumours and neuroblastoma for up- or down regulated AM proteins, and lung cancers for down regulated AM proteins.
The recent ability to integrate genetic mutations and altered protein expression to pharmacokinetics (PK) and pharmacodynamic (PD) models allow a deeper understanding of the mechanisms of disease and therapies that are genuinely targeted [ 5- 8].
Although HBV is not thought to be cytopathic, it is conceivable that enhanced viral replication and altered protein expression with different immunodominant epitopes may contribute to a more severe form of liver disease [ 25, 26].
