Sentence examples for altered propensity from inspiring English sources

Whether altered propensity to maintain wakefulness is a necessary condition of altered neural inertia remains unknown, but eminently testable in both mouse and fly models.

Certain properties of the mutated forms of Aβ such as posttranslational modifications and altered propensity to oligomerize/aggregate, could offer an explanation for the limited formation of structurally ordered Aβ fibrils in Arctic AD patients [ 41], whereas the underlying reason in the PS1Δ9 AD patients is even less clear, because the cotton wool plaques in such brains contain wild-type Aβ only.

Attaching them to proteins (via TG2) provides an elegant way to manipulate polyamine concentrations (organic cations) locally to be able to alter propensity for DNA (highly negatively charged due to phosphate backbone) to assume a compact (silenced) conformation.

Time has not altered the propensity of some in the church to attack Islam; only these days censure is just as likely to come from a small but significant number of black majority church leaders.

Previous studies examining TREM2-triggered phagocytosis had not examined whether prior cell activation altered the propensity of TREM2 to regulate microglial phagocytosis.

Thus, the dominant-negative effect of DISC1-607F on the nuclear and cytoplasmic distribution of wild-type DISC1 may be related to the potentially altered oligomerization propensity of this variant form of DISC1.

At low densities myofibroblasts did not alter arrhythmia propensity, at intermediate densities myofibroblasts caused additional APD shortening and increased arrhythmia propensity, at high densities myofibroblasts protected against arrhythmia by causing resting depolarization and blocking propagation.

Thus, the flanking sequence of the polyglutamine region does not simply alter the propensity to form a polyglutamine aggregate, but can directly affect its aggregation rate and responses, the subcellular localization of the inclusions, and the biochemical characteristics of the aggregates.

Cyclin D acts via TGF-β-Smad signaling to alter the propensity for endoderm versus neuroectoderm fate.

Accordingly, deletion in the C-terminal domain of PACAP reduces drastically the binding affinity without altering the propensity of the analogues to activate the receptor at high concentration (Bourgault et al., 2008b).

The functional impact of these variants was therefore further assessed by their potential to alter disorder propensity, a known disease-mechanism, using PONDR, as was previously undertaken (20, 21) (Fig.  4).