Thus, altered presentation of the APP substrate to γ-secretase, driven by either APP mutations or by binding of the pharmacological agents to APP could, in turn, allosterically affect PS1 conformation.
Weighing more abstract factors (e.g. contextual patient factors and altered presentation in time) probably leads to this fairly adequate clinical judgment of GPs [ 15- 17].
Intra-cellular replication of Salmonella resulted in reduced expression of pMHC-II complexes at the cell surface and altered presentation of antigen to CD4+ T cells.
The results indicate that the hypoallergenic nature of the rBet v 1 trimer is due to formation of defined high molecular weight aggregates which may be responsible for an altered presentation of IgE epitopes in a form with reduced capacity to crosslink effector-cell bound IgE.
Finally, we investigated whether our observations were specific to S. Typhimurium or if exposure to other bacteria also resulted in altered presentation to type B T cells.
Pulmonary microangiopathy occurs as a complication of DM and could partially explain the increased risk of lung infection for individuals with DM as well as the altered presentation of TB during co-morbidity[ 43].
