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Which factors contribute to altered organization of dermal collagen matrix in skin fibrosis is not well understood.
The resulting enlarged eisosomes show altered organization.
These data suggest that Golgi fragmentation reflects altered organization of intracellular trafficking, perhaps in response to specific aggregated SOD1 complexes.
This enhanced proximity to nutrients via an altered organization allowed a high-density hepatocyte culture closer to in vivo conditions.
The ECM produced by OA SBOs contained less mineral content, showed altered organization of matrix proteins and matrix structure compared with the matrices produced by normal SBOs.
We also used immunohistochemistry to assess whether the spinal dorsal horn of Entpd3 -/- mice exhibited altered organization in comparison with that of WT animals.
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Mutants deficient in different combinations of the four CRWN paralogs exhibit altered nuclear organization, including reduced nuclear size, aberrant nuclear shape and abnormal spatial organization of constitutive heterochromatin.
Recent findings of attenuated connectome alterations in unaffected siblings of schizophrenia patients suggest that altered connectome organization may relate to the vulnerability to develop the disorder, but whether it relates to progression of illness after disease onset is currently unknown.
As expected, pre-treatment of control HeLa cells with both inhibitors altered the organization of the actin cytoskeleton and prevented the formation of actin stress fibers upon irradiation (Figure 9A), confirming that these effectors were efficiently blocked.
However, further increasing collagen content altered matrix organization with a subsequent decrease in the failure strain.
It is now well understood that both losses and gains of DNA methylation as well as altered chromatin organization contribute significantly to cancer-associated phenotypes.
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