Several schemes that use elements within the vector design have been developed that allow an external drug or pro-drug to alter ongoing protein expression after in vivo gene transfer.
Now, FDA will have to decide whether to follow its advisers' recommendations normally, it does--and whether to add additional warnings to Avandia or demand that Glaxo alter ongoing studies, or launch new ones.
Unlike techniques that rely on magnetic fields or higher current to actively trigger neurons, such as electroconvulsive therapy, tDCS and tACS likely subtly alter ongoing brain activity, Bikson says.
The current work attempts to complement these studies by scrutinizing how modulations of tinnitus intensity alter ongoing oscillatory activity.
However, the results of conventional TTE were only given to the attending physician at the bedside and were potentially used to alter ongoing therapy.
He pointed out that the diplomatic initiatives have been working and have yielded positive results until now, with no need to alter the ongoing negotiation and diplomatic process.
This was striking, as stimuli that had been strong enough to trigger full network activations during network quiescence did not alter an ongoing spatiotemporal sequence when delivered during network coactivations.
If one of these units spontaneously switches to a weak state, this might not significantly alter the ongoing neuronal activity pattern, as long as each synapse is comprised of multiple individual contacts.
The idea of reconfiguration of resources is linked to the tradition of the RBV and the established notion that resources need to be altered on an ongoing basis reconfigured to create value (Eisenhardt and Martin 2000; Teece 2007; Helfat et al. 2007).
