Sentence examples for altered mouse lines from inspiring English sources

With the rapid increase in availability of genetically altered mouse lines (e.g. from systematic gene knockout programmes such as EUCOMM and KOMP), a consistent and sensitive method for identifying cardiac malformations in mouse embryos is essential [ 36 ].

Using genetically altered mouse ES cell lines (Mutant: AHF-Cre; AHF-GFP; Cdh2 fl/fl and wild type: AHF-Cre; AHF-GFP; Cdh2 fl/+), GFP+ AHF-CPCs were sorted and re-plated for staining of either membrane-bound β-catenin or nuclear-bound β-catenin molecules.

Using genetically altered mouse ES cell lines (Mutant: AHF-Cre; AHF-GFP; Cdh2 fl/fl and wild type: AHF-Cre; AHF-GFP; Cdh2 fl/+), GFP+ AHF-CPCs were sorted and seeded at 30 000 cells per well of a 96-well plate.

In 1988, Harvard University patented the first "transgenic" animal, a genetically altered mouse predisposed to getting cancer.

These results, however, appeared to be in partial disagreement with findings from genetically altered mouse strains.

Using these techniques, however, it can take over a year to create new lines of genetically altered mice, as the editing of embryonic stem cells is inefficient.

The NTP is evaluating several lines of genetically altered mice for possible use in identifying and assessing carcinogens.

Many lines of genetically altered mice have been generated during the past few decades in an effort to better understand the pathogenesis of AD.

Third, there have been various approaches to the development of battery testing (Crawley & Paylor, 1997); Shoji et al. (2012), for example, subjected two lines of genetically altered mice to a comprehensive test battery that included the forced swim test 5 days before the social approach test.

But the genetically altered mice become lost.

When he gave similarly altered mice antibiotics, their metabolic abnormalities disappeared.