The phrase "altered module" is correct and usable in written English.
It can be used in contexts related to programming, software development, or any field where components or modules are modified or changed.
Example: "The altered module improved the system's performance significantly after the update."
Alternatives: "modified module" or "revised module".
We also identify new candidate drivers in GBM, including AGAP2/CENTG1, a putative oncogene and an activator of the PI3K pathway; and, three additional significantly altered modules, including one involved in microtubule organization.
After significantly altered genes are detected, enrichment analysis is done to find significantly altered modules (e.g. biological processes or pathways) per experiment.
Previously, our group successfully applied the functional analysis strategy to identify altered modules in pre-malignant and adenocarcinomas of the stomach and esophagus [ 16].
Indeed, we identified altered modules with functions similar to those described by other authors using different approaches of functional gene expression in HNSCC.
In this study, we focused on the biology of the altered modules in pN0 vs. pN+ and in recurrent vs. non-recurrent tumors.
Expression of selected genes from altered modules was analyzed by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) in a ABI Prism® 7300 Sequence Detection System (Applied Biosystems, Foster City, CA) using 1X SYBR Green PCR Master Mix Applied Biosystemss, Foster City, CA).
For instance, the altered modules harbor genes that are frequently studied in cancer but also suggest a role for some genes that have not been previously implicated in HNSCC or metastasis in general.
We performed integrated network analysis to identify frequently altered network modules and candidate driver mutations in glioblastoma.
These expression changes were integrated with our protein-protein interaction network and used to identify significantly altered genetic modules.
