The p.His137Asp mutation (detected in 1 patient) altered a moderately conserved amino acid.
This variant altered a moderately conserved AA in the ND6 polypeptide.
Another patient carried a de novo missense mutation in PTEN, altering a moderately conserved threonine to an alanine (p.T78A).
The cohort had a mean age of 55 years and a moderately altered physical performance (mean KPS: 81; most frequent symptoms on enrolment: cephalalgia, alterations in higher cerebral functions, long tract signs and epilepsy in six out of nine, four out of nine, eight out of nine and three out of nine patients, respectively).
The neurobehavioral performance of the offspring might be moderately altered due to maternal exposure to TiO2 NPs [71].
In this work, the retardation of sodium, calcium and strontium was studied on mica gneiss, unaltered, moderately altered and strongly altered tonalite using dynamic fracture column method.
Additionally, p21WAF1/CIP1 protein levels were upregulated in cancer stem cells depleted of c-Myc, whereas p53 levels were only moderately altered (Figure 2B).
Thus, genetic and biochemical analyses like the ones described in this paper appear to be essential to decipher the function of specific isoforms, whose levels are moderately altered during Drosophila development.
We found that most genes are connected with the NF-κB nodule (Fig. 5B): Highly activated was the cytokine IL-1, moderately altered are ICAM1, CDKN2B, TNF, BIRC3, Fas, Tank, BCL2A1, chemokine (C-C motif) ligand 2 (CCL2) and CCL20.
