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Taken together, the cumulative data support a model in which DNA damage signaling and repair pathways are altered in TICs and lead to an altered mode of cell death with unique consequences for long-term clonogen survival.
Detailed analysis showed that the crizotinib acquired an altered mode of binding in both the mutant complexes.
E. falciformis possesses a reduced set of transmembrane transporters and we suggest an altered mode of iron uptake in the genus Eimeria.
We hypothesize that this might be due in part to the altered mode of substrate selection that we have observed for Hsp104A503V.
In the post hoc analyses investigating systematic alterations in BOLD response over time in the scanner (i.e. BOLD effects potentially associated with a qualitatively altered mode of cognitive processing of the emotion stimuli over the course of the experiment), no trends were seen.
Disruption of the planar indolocarbazole ring system through the sp hybridization of the two carbons at the base of the pyrrole ring in the indolotryptoline structure is likely to lead to an altered mode of binding of this class of tryptophan dimers.
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Nonetheless, the cumulative data support a model in which DNA damage signaling and repair pathways are altered in TICs and lead to altered modes of cell death with unique consequences for long-term clonogen survival [ 13].
Additional file 2 provides a list of all bimodal genes with altered modes of expression in diabetes.
Moreover, bimodal genes with altered modes of expression were identified in microarray data for type I and type II diabetes (Table 2) [ 6, 29, 40, 41].
We had also evaluated the expression of the bimodal genes in disease states for diabetes types I and II to reveal some of these genes with altered modes of expression in the disease state, revealing the roles of these genes in cell communication and immune response.
The technique is based on the split-mode phenomena that occurs when the degenerate vibratory modes of the axisymmetric structure become non-degenerate due to the flaw with altered mode shapes and shifted natural frequencies.
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