Sentence examples for altered locus from inspiring English sources

The TCIS system allows Cre-recombinase-mediated site-directed integration of any DNA fragment into a locus tagged with lacO arrays, thus enabling both functional molecular studies and positional analysis of the altered locus.

Results for individual markers revealed that D3S1619 represented the most frequently altered locus since, only considering informative cases, 20 of 61 tumours (32.7%) showed LOH at this chromosome locus.

Chromosomal gains and losses thus lead to increased or decreased numbers of mRNA molecules that are transcribed from the altered locus, thereby providing a proliferative advantage to the cell.

Expression study of the gene identified at the altered locus was done by semi-quantitative reverse-transcriptase-PCR (RT-PCR).

DSBs that are repaired by HR using either the sister chromatid or homologous chromosome as a template do not result in an altered locus and are not detectable.

With regard to the number of altered loci, 18 tumours (51%) showed alteration at only one locus and 11 (31%) showed alterations at multiple loci (Table 3).

Although we have implicated thirteen contingency loci in host adaptation and enhanced virulence, the functions during pathogenesis of these altered loci are not well established.

The assumption is that altered loci spanning observed variations in the genome should be removed given their ambiguity of origin, being either somatic possibly oncogenic or germline polymorphic.

Because of their highly altered genomes and the large volume of data generated by array analyses, simple visual inspection of altered loci proved inefficient to identify minimal recurrent regions of aberration.

Our finding of transmission of altered, locus-specific DNA hypermethylation which is induced by an inherited constitutional translocation and associated with a neurodevelopmental disorder is reminiscent of that observed in cancer (23).

Separate correlation matrices (Fig. 4) were created using the most commonly altered loci (Table 1).