Sentence examples for altered interaction from inspiring English sources
Only some of the direct effects can be inferred as direct consequences of inhibition of histone deacetylation, and others are the results of other mechanisms, such as the inhibition of transcription factor deacetylation, resulting in an altered affinity for DNA binding sites on target gene regulatory regions, an altered interaction with other factors or an altered half-life [ 74].
The S272G mutation abolished both responsiveness towards TLC (TGR5 dependent) and forskolin (TGR5 independent), suggesting altered interaction of TGR5 with downstream signaling targets.
Thus the inability of the H486R mutant to inhibit NF-κB activation is mainly due to its altered interaction with CYLD although reduced binding to ubiquitin may also contribute to some extent.
However, the inhibition will lost after PLN is phosphorylated at position 16 or 17 by cAMP- or calmodulin-dependent protein kinases, resulting in the dissolution of PLN/SERCA complex or an altered interaction between the two proteins [5], [6].
It can be argued, however, that the abnormal AMP status of IBD patients is the consequence of an altered interaction between barrier and microflora interaction rather than a causative factor for disturbed microbial clearance.
The exact disease aggravating mechanism is not known, but altered interaction with ligands [10] as well as defects in leukocyte trafficking and uptake of apoptotic cells or immune complexes have been suggested [14].
Analysis of the structure of the KRAS(G48A) mutant predicted altered interactions with other proteins.
Two base pair deletions in NL4 have been found in male autistic patients, resulting in altered interactions with β-Nrxs (Laumonnier et al., 2004).
As a complex disease, CVD is the consequence of multiple pathogenic factors and reflects the altered interactions of many interconnected genes and gene products [9].
Importantly, all bacterial preparations of PP1C displayed altered interactions with the regulatory subunits.
Many common diseases, such as asthma, diabetes or obesity, involve altered interactions between thousands of genes.
