The level of vacuum can be altered individually, although the best results have been demonstrated with a pressure of 125 mmHg [2, 10].
The level of vacuum can be altered individually, although the best results have been demonstrated with a pressure of 125 mmHg [ 2, 10].
Simulation of experimental conditions in which the expression levels of rhodospin kinase (RK), of the regulator of the G-protein signaling (RGS), of Arr and of Rec were altered individually or in combination revealed severe kinetic constraints to the dynamics of the overall network.
Moreover, because our intent was to explain observed trends rather than to make future predictions, we adopted a specific approach that consisted in altering individually the value of each parameter during a given simulation (as was done in [ 1] with treatment rates of all persons), rather than running simulations with a set of fixed parameters and comparing outcomes across runs.
Additional, while no strict statistical cut-off was used to assess genes individually altered by copy number alteration in the original analysis, many of the genes that are targets of high-level focal amplification or homozygous deletions, including EGFR, CDK4, CDKN2A/B, PTEN, MDM2 and MDM4 are all also identified within the GBM network.
Green and grey rectangles indicate drug effector and drug non-effector pathways, respectively; red and white circles represent individually altered and wildtype genes, respectively; normal and bold lines indicate normal and ectopic activated pathway signalling, respectively; and flash signs indicate drugs targeting specific molecules.
To identify them, we conducted EMSA experiments with linker scanning mutant probes, in which GC-rich regions, known to be preferentially bound by E2F factors, were individually altered to poly-A stretches (Fig. 4B).
To provide optimal treatment, pump settings will be individually altered to the extent that the physician would consider necessary, based on the findings of physical examination and parental and patient interview, as were the patient not participating in the study.
We individually altered the charge character of 27 basic residues along the C-terminal tail of human TRPA1 and examined the membrane current responses to voltage, AITC or a combination of the two.
Inhibition of DNA polymerases α, δ and ε by AFP promoter-driven artificial microRNAs may lead to effective growth arrest of AFP-positive HCC cells, which may represent a novel strategy for gene therapy by targeting the genes that are essential for the growth/proliferation of cancer cells, avoiding the limitations set by any of the individually altered gene.
Since the production of MMP-2 in normal cells is regulated by the growth factors and cytokines, this heterogeneity seems to be due to differential properties of individually altered neoplastic cells in terms of the expression of specific receptors for these agents [ 25].
