The phrase "altered in isolation" is correct and usable in written English.
It can be used when discussing changes or modifications made to something without considering its context or surrounding elements.
Example: "The data was altered in isolation, leading to results that did not reflect the overall trends."
Alternatives: "modified independently" or "changed without context".
While primary cells are a good tool for modeling in vitro, their phenotype can alter in culture in isolation from normal neighboring cell types.
It remains to be answered whether and to what extent these described in vitro properties reflect the in vivo function of perivascular MSCs as these properties might be altered upon isolation and culture in vitro.
This finding raises the possibility that two CM mutant alleles, that in isolation markedly alter cell performance to cause CM, could in combination yield near normal cellular physiology.
Notably, restoration of any of these targets in isolation did not alter the metastatic potential of sarcoma cells injected orthotopically, but the simultaneous restoration of all 4 targets together substantially decreased the number of metastases.
Similarly, the ingredient-mixture relationship exemplified in (10) is of dubious mereological status, as the ingredients may undergo significant chemical transformations that alter the structural characteristics they have in isolation (Sharvy 1983, Bogen 1995, Fine 1995a, Needham 2007).
Such small ischemic lesions ("silent stroke", cortical microinfarcts; Kovari et al., 2007), which in isolation would not alter cognition, substantially aggravate dementia, indicating that cerebral ischemia may interact with AD pathology.
The effect of altering this single nucleotide was therefore investigated in isolation in the color-normal wild-type L- and M-genes.
But these connections don't alter their basic isolation.
It is clear that the epigenetic states of two different genomes in the same nucleus do not function in isolation but interact to produce altered epigenomes.
Just as single interventions have failed to alter outcomes in severe sepsis, it seems highly unlikely that the measurement of biomarkers in isolation from an associated "package of care" will alter critical care outcomes.
