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Similarly, protein levels of ER-resident chaperons BIP, PDI, Hsp90 were not significantly altered in aortas of AKO mice.
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SA-β-gal activity, indicated by blue color, was strong in aortas of male db/db mice, weak in aortas of female db/db mice, and absent in aortas of male or female wild-type mice.
Furthermore, the second objective was designed to determine whether the celiprolol-induced relaxation was altered in spontaneously hypertensive rat (SHR) aorta, and to evaluate the effect of systemic or local angiotensin II (AngII) AT1 receptor (AT1R) antagonism on the relaxant effect of celiprolol.
The results demonstrated that in normal condition KATP channels participated in the constriction process of aorta, but their structure and/or function were altered in HF model and these alterations were not mitigated by the treatment of DMC and ATV.
Endothelium-independent dilation, measured by the relaxation of aorta in response to sodium nitroprusside, was not altered in ApoE−/−/ Cyp1b1 +/+ mice fed ND or AD with or without TMS.
The regional expression of HOX genes in the baboon aorta led us to hypothesize that HOX gene expression might be altered in human AAA.
Furthermore, the telomerase activity in the aortas of male db/db mice was significantly lower than that in the aortas of female db/db mice (P < 0.01).
Whereas Ltbp4S−/− aortas exhibited only moderate disruptions of the IEL adjacent to the endothelial lining, disruptions were significantly more severe in the aortas of Ltbp4−/− mice (Fig. 2I).
SSR240612 failed, however, to alter basal O2− production in the aorta of control rats (Figure 6A).
The latter treatment with the B1R antagonist failed to alter O2− production induced by NADPH in the aorta of control rats (Figure 6B).
To determine whether endothelial-specific Nox2 overexpression altered lipid deposition in the descending aorta, excised aortas were stained with Oil red O.
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