Sentence examples for altered highly from inspiring English sources

Interestingly, the non-synonymous changes in haplogroups J1 and N1b1 altered highly conserved amino-acid positions in OXPHOS complex I, implying that they possibly affect the activity of this complex [ 40].

The treated animals were sacrificed and the samples were analyzed 1) with 5 months - when first plaques and early dendrite degeneration can be identified in APP 23 mice - to detect protective effects and 2) with 11 months to clarify whether β1 antibody treatment allows recovery of altered highly ramified commissural neurons after a 4-month-treatment period.

We identify in ~60% of SPTCL cases germline, loss-of-function, missense variants altering highly conserved residues of TIM-3, c.245A>G (p.Tyr82Cys) and c.291A>G (p.Ileachet), each with specific geographic distribution.

Here, we have shown that a variety of mutations, designed to disrupt individually three pseudoknot (PK) structures and alter highly conserved nucleotides among the CrPV-like viruses, inhibit IGR IRES-mediated translation.

The most strongly dominant alleles alter highly conserved residues of the myosin ATP binding site, indicating that functions of the myosin ATPase are important for thick filament assembly.

Interestingly, however these mutations alter highly conserved amino acids present in all Rab GTPases, suggesting that they are critical to the function of these small GTPases.

These changes are in the central intervening region of Keap1 and alter highly conserved amino acids.

Of note, the tumors without AKT1 in-frame duplications often had two or more point mutations altering highly conserved residues.

In silico analyses revealed that all of the functionally characterized human Cx50 missense mutations alter highly conserved residues (Supplemental Figure 1; multiple sequence alignment provided as supplementary text).

All known mutations in CMT2B patients alter highly conserved amino acids in Rab7 and cause pathology in heterozygosity (Kwon et al., 1995; Verhoeven et al., 2003; Houlden et al., 2004; Meggouh et al., 2006).

SIFT Ng and Henikoff, 2006 and AlignGV-GD Tavtigian et al., 2006, for example, use multiple alignments to assay conservation levels of novel amino acid changing variants with the underlying assumption that sequence variants, which alter highly conserved positions in protein sequences are a priori more likely to be damaging.