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A way forward on how mutations of the SBDS gene (sbds) may relate to its altered functions is via a functional genomics approach and phylogenetic analysis of gene proximity in sbds loci.
Another possibility is that the particular sequence variations may induce alternative/ de novo splicing creating a non-functional receptor protein or receptor with altered functions.
Pathologically altered functions of astrocytes and microglia play a pivotal role in diseases of the central nervous system (CNS).
She was best known for her work on prions — proteins that exhibit an unusual ability to exist in multiple stable structural states, with altered functions depending on the state.
However, Samsung has progressively taken out or altered functions to avoid infringing Apple's intellectual property.
Human cancers arise from a series of mutations, many of which direct the expression of mutant proteins with altered functions.
New exon combinations can be generated by recombination within the intervening intron sequences, yielding new rearranged genes with altered functions.
Therefore, altered functions in various CAMs contribute to the pathogenesis of AD, although the precise underlying mechanism is still unknown.
The morphologic characteristics of the astrocytoma microvessels are similar to the histologic changes seen in astrocytoma tissue in situ, and correlate well with the known altered functions of brain tumor neovasculature.
A prior limitation to the phantom was that it did not accurately simulate altered functions of the heart that result from cardiac pathologies such as coronary artery disease (CAD).
Conversely, signatures are clearly not capturing the altered functions in the corresponding studies.
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