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In rats, this altered exposure to reproductive hormones produces accelerated reproductive aging and a hormonal environment that is conducive to mammary tumor development.
The hygiene hypothesis concedes that current hygiene practices lead to reduced or altered exposure of bacteria and other micro-organisms that may result in an imbalance of the immune system and microflora early in life.
The hypothesis of a causal relation would be supported if an altered exposure to cigarette smoke, for example smoking cessation, could be shown to reduce the risk of stillbirth.
These observations suggest that elevated numbers of MCMV-reactive CD8+ T cells were not a consequence of altered exposure to viral antigens, and that a ∼2-fold increase in virus-specific CD8+ T-cell numbers does not reduce MCMV burden during acute infection of 4-1BB−/− mice.
Altered exposure to microbial organisms in early life might influence the development of atopy.
INM defects caused by a dynactin mutation result in altered exposure to Notch signals and impair neurogenesis in zebrafish retina (Del Bene et al. 2008).
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In conclusion, we have shown that the prolonged circulation of SN-38 at low concentrations following CPT-11 administration has clinical implications, and resulted in altered exposure-toxicity relationships.
Other effects may be felt in more indirect ways, such as through altered exposures to chemicals and pathogens whose use and spread, respectively, may shift in response to climate change.
To protect children's health, it is prudent to initiate programs designed to alter exposure to well-established leukemia risk factors rather than to suspend judgment until no uncertainty remains.
It was concluded that coadministered ritonavir and PA interact to alter exposure to artesunate, DHA, and ritonavir itself.
Changing the year (1990) or location (MacArthur Airport) of meteorological data collection for a sensitivity analysis did not appreciably alter exposure estimates (Beyea et al. 2005).
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CEO of Professional Science Editing for Scientists @ prosciediting.com