Exact(1)
This result suggests that the −765G→C change induces an altered enzyme expression and enzyme activity with potential anti-inflammatory consequences.
Similar(59)
This is because single nucleotide polymorphisms can alter enzyme activity and expression levels.
These include reduced stature, hypercorticism in the absence of elevated adrenocorticotropic hormone levels, increased metabolic efficiency, decreased mitogenic response coupled with increased rates of apoptosis, reduced inflammatory response, induction of stress proteins and DNA repair enzymes, altered drug-metabolizing enzyme expression, and modified cell-mediated immune function.
When enzyme expression is altered by genetic engineering, acetylcholinesterase levels on the outer surface of transfected neurons correlate with ability to extend neurites.
Leydig cell number in the Tfm is 60% controls (19), associated with a significant reduction in T production despite high levels of circulating LH (20, 21), which implies that steroidogenic enzyme expression is also altered.
3, 4 Growing evidence has linked altered lipid protein redox-homeostasis (LPRH), antioxidant enzyme expression, and renal dysfunction.
Similarly, ketone-metabolizing enzyme expression also appears to alter.
The presence of polymorphic alleles for cytochrome P (CYP) 450 may result in lack of expression, altered levels of expression, or altered function of CYP450 enzymes.
The impact of changes in intracellular cAMP concentration on trypanosomes is evidenced by the severe phenotypes upon altered expression of enzymes involved in cAMP metabolism.
The BRC-resistance of prolactinomas is associated with several processes including drug efflux by transporters, inactivation by detoxifying enzymes, altered expression of pro-/anti-apoptotic proteins or tumor suppressors, and increased activity of DNA repair mechanisms [ 34, 35].
Pierce, V.A. & Crawford, D.L. Phylogenetic analysis of glycolytic enzyme expression.
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