The phrase "altered downstream" is correct and usable in written English.
It can be used in contexts related to processes, systems, or workflows where changes occur later in the sequence of events.
Example: "The data was altered downstream, affecting the final results of the analysis."
Alternatives: "modified later" or "changed further along".
Communities of microbes that help support life were dramatically altered downstream.
Adding to the complexity, recent findings demonstrate that extracellular binding changes between EPO and EPOR due to EPO variant result in selectively altered downstream signaling responses, which reveals a mechanism in EPO/EPOR signaling modulation45.
In two cases with no drug effect, the drug is not targeting the perturbed pathway or altered downstream genes gained ectopic activation independent of upstream stimulation, so treatment is ineffective.
Damming of the Canning caused dramatic flow reductions that significantly altered downstream aquatic macroinvertebrate communities.
This suggests that Jurkat E6.1 T cells have reduced levels of TCR-induced ZAP-70 activation and potentially have altered downstream signaling.
We examined whether GmMYB73 altered downstream gene expressions through suppression of GL2.
Dams strongly impair the fluvial environment by altering downstream flows.
Mutations mediate oncogenic effects by altering downstream signaling and anti-apoptotic mechanisms [1, 7].
Therefore, absence of a developmentally expressed transcription factor can alter downstream gene expression and multiple signaling pathways in organogenesis.
From this data, we would hypothesize, that the increased glycogen stores are causing a negative feedback reducing AMPK activity, and potentially altering downstream proteins in the insulin stimulated glucose pathway (Figure 5) thus reducing glucose uptake.
In addition to promoter polymorphisms, epigenetic modification can alter downstream gene expression.
