The phrase "altered down" is not correct and does not convey a clear meaning in written English.
It is unclear what is intended by "altered down," as it does not follow standard usage patterns in English.
Example: "The design was altered down to fit the new specifications." (Note: This example is not ideal due to the phrase's lack of clarity.)
Alternatives: "reduced" or "modified".
PTPN2 was significantly altered (down-regulated) in expression and mapped to the MEN (Additional file 5: Table S5).
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9 10 Main mechanisms are an increased release of excitatory neurotransmitters at spinal level, influencing pain perception via the spinothalamic pathway and altered top down pain control from the brain.
Microarray analysis data demonstrated that long-term potentiation (LTP) pathway was altered with down-regulation of genes against OS.
Interestingly cytokine-cytokine receptor interaction pathways were severely altered by down-regulation of 19/21 genes in KEGG PATHWAYS (not shown), 197 genes of signal transduction and 33 out of 271 inflammatory genes (Table 6).
In other words, among all the genes, PIAS2 would the most likely cause the ESC-to-EB transition of the pathway behavior (probability 0.0035 in human and 0.014 in mouse) when its initial transcription state of up-regulation in ESCs is altered to down-regulation (Table S3).
We hypothesized that the dopaminergic neurotransmission during development may be altered by down-regulation of otpb gene.
In our case however, Pax7 was not found altered following down-regulation of myogenin by TWIST either in presence or absence of growth factors [ 38].
Upon temperature changes, herbivores, on the other hand, face bottom-up changes in plant host quality, show direct physiological and reproductional responses [ 55], plus are confronted by altered top-down control from natural enemies [ 59].
Apoptosis-related genes (Table 3 and Additional file 3) were variously altered, including down-regulation of BCL2 in SSc-MVECs, which also exhibited a general pro-fibrinolytic pattern, coupled with over-expression of PTX3, which increases tissue factor expression and stimulates generation of inflammation mediators, [ 31].
