The phrase "altered domain" is correct and usable in written English.
It can be used in contexts related to changes in a specific area of expertise, field, or environment, often in technical or academic discussions.
Example: "The researchers focused on the altered domain of genetic engineering to explore new possibilities in biotechnology."
Alternatives: "modified domain" or "changed domain".
9/16 patients exhibited altered domain specificity profile at relapse.
Analysis of longitudinal samples revealed that patients that relapsed may have an altered domain specificity profile from those at first presentation (Fig. 6B C).
Toward this end, evaluation of the elastase inhibitory potential of the HS samples used in this study has indicated differences that might relate to altered domain organization.
It frequently results from differential exon inclusion and leads to altered domain composition, subcellular localisation, interaction potential, signalling capacity, and other changes at the protein level.
Introducing this bulky side chain would be expected to sterically hinder alignment of the SH2 and kinase domains, resulting in an altered domain packing.
One challenging aspect is the loss of specificity and activity of unnatural substrates or altered domains.
The effect of the 3 amino acid replacements present among RLK allotypes, A87V, Q115K and H274N were predicted to alter domain stability and function.
Such length variations, caused by indels, were shown to play a principle role in introducing important evolutionary signatures in form of changing substrate specificity, altering domain interactions and sometimes even regulating protein stability [ 8].
To investigate which domains of LEDGF/p75 are involved in the nuclear FRET increase, we generated a series of LEDGF/p75 mutant constructs, specifically deleting or altering domains involved in chromatin binding (Supplementary Fig. S8) and reintroduced these to complement LEDGF/p75KD cells.
It is possible that these changes in amino acid composition of the forkhead domain alter the domain configuration thus allowing for different target binding and/or regulation of FoxA genes in the Protostomia as compared to the Deuterostomia.
Once it had access to Melbourne IT, it altered the domain records of the Times and Twitter.
