Sentence examples for altered disposition from inspiring English sources

Pharmacokinetic data from this trial demonstrated that in comparison to the nonliposomal drug, the liposomal formulation OSI-7904L halteredredispositionon properties and exhibited a longer plasma circulation time.

Enhanced distribution of epirubicin from the serum and altered disposition might, in fact, explain the increased level of myelotoxicity in this pilot as well as in other clinical phase II studies involving DVPM.

Altered disposition for sulfamethazine (SMZ) when concurrently administered with flunixin meglumine (FLU) in swine could lead to increased tissue residues.

This event is also associated with altered disposition of loops (switch 1, switch 2, and P-loop) at the catalytic site (see further below).

These results suggest that RRMS does not alter disposition of peginterferon beta-1a.

The issue of stress during the placement of implanted devices, and also the possibility of chronic inflammation that can alter disposition of many substances and hormones, however, requires further attention.

Critical illness may further exacerbate these circuit interactions of nutrients, and future studies should further evaluate altered nutrient disposition during ECMO and their potential impact on clinical outcomes.

In mouse models of cholestasis norUDCA induces basolateral multidrug resistance-associated proteins 4 and 3 (Mrp3, Mrp3) in hepatocytes, which provide alternative escape routes for bile acids accumulating during cholestasis but could also result in altered hepatic disposition of concomitantly administered substrate drugs.

In these studies, afucosylated trastuzumab displayed moderately altered pharmacokinetic dispositions compared with trastuzumab, slightly faster elimination from the circulation, and a modest reduction in half-life (Junttila et al. 2010).

Neither the model nor the in vivo study revealed clinically significant changes that alter tissue disposition.

The U.S. economy needs more capital in the next ten years than it knows how to obtain without sharply altering the disposition of the nation's wealth.