Sentence examples for altered differentiation from inspiring English sources

In addition to cytokines and pathogens, NFkB and Jun proteins respond to various cell damaging factors, including free radicals and other genotoxic agents that can cause apoptosis, growth arrest, altered DNA repair or altered differentiation.

Absent or altered differentiation is one of the major features of cancer cells.

This impairment was due to decreased cell proliferation and survival and not due to altered differentiation.

The underlying pathogenesis involves three predominant and interdependent biologic processes: inflammation, epidermal hyperproliferation, and altered differentiation with parakeratosis.

Cells immortalized with human telomerase have shown no signs of tumorigenesis, altered differentiation, or deregulation of cell proliferation [11].

Because FLG2 expression strongly depends on terminal differentiation of keratinocytes, the decreased expression of FLG2 might be caused by the altered differentiation in the psoriatic plaques.

The disease is believed to be primarily mediated by T-cells, which release cytokines that stimulate keratinocyte (KC) hyperproliferation and altered differentiation [1], [2].

Here, loss of E-cadherin resulted in death of mice shortly after birth due to dehydration [41], altered differentiation [39], and disturbed epidermal integrity [40].

The contribution of IL-20 and IL-22, cytokines produced by keratinocytes and T cells, to altered differentiation in psoriatic keratinocytes is currently discussed [7], [8].

In contrast, PMA treatment followed by 5 days resting in culture without PMA (PMAr) increased cytoplasmic to nuclear ratio, increased mitochondrial and lysosomal numbers and altered differentiation-dependent cell surface markers in a pattern similar to MDM.

These altered differentiation-related molecules could be reversed by the ERK inhibitor PD98059.