Acidosis and low oxygen significantly altered components of the redox system.
Emerging evidence suggests that altered components and post-translational modifications (PTMs) of proteins in the ECM may both initiate and drive disease progression (Leeming et al., 2011a).
When moderate, the macroautophagic activity enables senescent NHEKs (i) to escape autophagic programmed cell death and (ii) to ensure the elimination of various accumulated altered components, especially the oxidized ones, which could be deleterious.
We recently reported that 5-week exposure to environmentally relevant levels (10 and 100 ppb) of As in drinking water significantly altered components of the innate immune response in mouse lung, which we hypothesize is an important contributor to the increased risk of lung disease in exposed human populations.
These tenets are supported through experiments that alter component amounts through protease digestion, vessel remodeling, normal growth, or in different artery types.
Minimization of cement strain, especially at the crucial proximal and distal areas of the stem, by altering component design may be able to reduce cement prosthesis debonding and improve clinical results.
The WSJ is reporting that HTC is now working with Qualcomm to alter components to prevent another possible lawsuit.
Similarly, for disaster risk governance systems, we can expect disasters to alter components of the system, at least temporarily – whether perturbations are low-intensity but frequent or singular, high-intensity events.
A wave of new research has incorporated a multispecies community context, showing that additional ecological interactions can alter components of host and parasite fitness, as well as interaction specificity and virulence.
Overexpression of Wnt4 may interrupt such a relationship, by either changing the cell membrane structure of chondrocytes or altering components of the ECM.
