Sentence examples for altered compartmentalization from inspiring English sources

To understand whether the increased DA steady state level in the striata of old A53T-SNCA overexpressing mice is accompanied by enhanced synthesis, decreased degradation or altered compartmentalization of DA, the expression levels of different enzymes and transporters responsible for DA homeostasis were determined (Table S1).

Studies by our group have shown altered compartmentalization of activin A in asthmatic airway epithelium and bronchoalveolar lavage (BAL) in the mouse [ 18, 19].

This suggests that altered compartmentalization of sucrose hydrolysis along with increased glycosylation may have altered phenylpropanoid flux in the fed cells.

Thus, reduced SMAR1 expression in cell lines derived from IDC G-III sample can be attributed to the altered compartmentalization of mutant p53.

These results suggest a cellular alcohol tolerance leads to altered compartmentalization of RACK1.

Interestingly, the altered compartmentalization of RACK1 in response to alcohol exposure in specific brain regions also contributes to neuroadaptations that underlie the development of alcohol addiction.

The acute regulation of hepatic GK in response to feeding and fasting is poorly understood, partly due to the added complexity of altered subcellular compartmentalization of GK in response to these conditions and also because of the impact that the glucose-6-phosphatase system of the endoplasmic reticulum may have on glucose and glucose 6-phosphate levels and glucose uptake and release [ 7, 62].

They also act at the cytoplasmic level to regulate several intracellular effectors by increasing the levels and altering the subcellular compartmentalization of, for example, Stat 5, and by potentiating mitogen-activated protein kinase (MAPK) and Janus kinase activities [ 14].

Moreover, in T3 kd MES13 cells FoxO1 compartmentalization was also altered, and a decrease in the nuclear Foxo1 pool seemed to entirely account for the overall reduction of protein level observed in total lysate of T3 kd MES13 cells, as was observed in STZ- Timp3 −/− mice (Fig 5A).

Even proteins with homologs of known function may have a different biological role due to altered regulation, posttranslational modification, or cellular compartmentalization [4], [5].

This compartmentalization and water management activities altered the hydroperiod and produced a gradient of drier to wetter conditions from north to south, respectively, in each of the constructed impoundments.