The phrase "altered cell lines" is correct and usable in written English.
It can be used in scientific or medical contexts to refer to cell lines that have been genetically modified or otherwise changed for research purposes.
Example: "The study focused on the effects of a new drug on altered cell lines derived from cancer patients."
Alternatives: "modified cell lines" or "transformed cell lines".
Since the K- ras 4A/4B ratio is reduced in primary CRC tumours [ 12] the altered ratio in cell lines, including those that lack K- ras activating mutations, is more likely to be symptomatic of the tumours from which they were derived rather than an in vitro artefact of the growth conditions.
We chose to study the impact of the presence or absence of estrogen, based on its association with altered expression in TNBC cell lines and tumors.
Altered growth characteristics in cell lines subjected to selection pressure has frequently been reported, but the underlying cause has rarely been identified, and generally the selected lines grow more slowly (Louie et al, 1992; Gibelli et al, 1996; Hochachka et al, 2002).
Key findings of various altered pathways outlined above are consistent with previously characterized gene expression alterations in various cell lines, primary cultures of HGPS patients as well as those from normally aging control individuals.
To better understand the interrelationship between these enzymes in mammalian cells and their effect on important cellular phenotypes such as oxidative stress-induced mutagenesis, the availability of mouse fibroblasts cell lines with altered expression of these two polymerases could be invaluable.
Similarly, we observed that acute benzopyrene exposure is associated with altered methylation patterns in these cell lines.
Long-term cell culture in vitro may generate genetic instabilities and the derived cell lines with altered cell biological features have been utilized as cell models for in vitro studies [ 17, 18].
Cell viability, apoptosis, invasion, and colony formation assays were used to assess the altered phenotypes of esophageal cancer cell lines after miR-224 expression or inhibition.
The column "Protein levels" shows how often corresponding changes of the protein levels were identified by Stingele et al. [ 15] (number of cell lines with altered protein expression/number of cell lines where the protein was quantified; NA – proteomics data not available).
The observations described above were based on the number of proteins showing altered expression profiles in the transgenic cell lines.
