By day 21, after 7 days of low-dose concentrations of IL-1β, all constructs showed continued mechanical functionality that was not significantly altered by the addition of the cytokine (p > 0.05, Fig. 6a).
As suggested in a recent work, there is a lack of mouse models where the functionality of main effector genes of the PI3K cascade is altered by the manipulation of their regulators [ 47].
Disrupting the lipid rafts' integrity, which are plasma membrane microdomains rich in cholesterol, may modify tumorigenic processes by altering the functionality of CD44, which is a cell surface receptor involved in cell migration and tumor metastasis [ 150, 151].
Inherited polymorphisms in cellular viral sensor genes are potential determinants of immune response heterogeneity that may influence the immune responses by altering the functionality and antiviral effects of the corresponding proteins.
These alterations may subsequently alter the functionality of the ASV as compared with the engineered or metalloprotease-generated soluble receptors.
The physical relation between reader and transponder is altered to validate the functionality of the program and to evaluate its influence on its power consumption.
Furthermore, co-delivery of the GM-CSF DNA altered the functionality of HA-specific T cells but this effect markedly differed between the two compartments.
C/EBPβ might serve as a signal-dependent docking platform for epigenetic enzymes that once recruited may also alter the functionality of C/EBPβ by decoration with additional PTMs that, in further analogy to the histone code, may serve as docking/blocking/assembly sites for novel-interacting complexes.
Since the treatments did not alter the levels of expression of this protein, this increase must occur through mechanisms that alter the functionality of ERα.
Protein functionality is altered by TGase-induced cross-linking [ 21, 22] which alters the heat-induced gelling ability of muscle proteins [ 23, 24].
