As part of an integrated system with DNA methylation, histone methylation is theorized to be part of a complicated histone code that is composed of a variety of other posttranslational modifications and that is altered by environmental signals and disease pathologies to control gene expression.
"It can be altered by neglect.
Patrick Cariou photograph, as altered by Richard Prince.
Again, this effect was altered by irradiation.
This could be mediated on the molecular level, e.g., by altered posttranslational modification of Nrf2, altered binding partners in the coactivator complex, or altered binding behavior at ARE-dependent promoters (duration, strength, preference for certain promoters).
Even proteins with homologs of known function may have a different biological role due to altered regulation, posttranslational modification, or cellular compartmentalization [4], [5].
In virus infected plants, protein activities are often altered through posttranslational modifications such as ubiquitination [ 4].
Chromatin structure can be altered both by histone posttranslational modifications (such as acetylation), which alter histone/DNA or histone/histone interactions, and by ATP-dependent chromatin remodeling complexes (such as SWI/SNF) [68].
The authors did not perform Western blot analysis to determine whether there is altered posttranslational expression and/or processing of SGLT1 and GLUT2.
A study by Brown et al. calls for alternative approaches by targeting different histone modification pathways to alter other posttranslational modifications on histones such as H3S28 phosphorylation which can minimize the dominant negative effect of H3K27M (Brown et al. 2014).
