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The clinical implication is that pathological levels of plasma sVEGFR1 may not necessarily indicate altered sVEGFR1 production or altered availability of free VEGF, because they may partially reflect altered receptor expression in tissues.
3D response surface indicated that the altered availability of the two ions (Mn2+ and Mg2+) reduced their effects on SMase activity.
Altered availability of IDPs is associated with diseases such as cancer and neurodegeneration.
Instead, these defects are most likely due to altered availability of substrates for complex I (NADH) and II (FADH2).
Disease-causing altered availability of IDPs may result in imbalances in signaling pathways by sequestering proteins through nonfunctional interactions involving disordered segments (i.e., molecular titration).
Neurotransmitter levels and function can be affected by changes in the plasma concentrations of various amino acid precursors, and some investigators have proposed that altered availability of large neutral amino acids contributes to the development of delirium [ 32].
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Although the authors recommend that treaties or other agreements "should address how riparian states will adapt to altered timing and availability of flows," the prospects for that kind of adjustment are poor.
In conclusion, we have demonstrated that the severe delay in the viral life cycle of attB-Ad helper virus is not caused by abnormal viral DNA replication nor by altered levels or availability of viral proteins.
Another feature of globalization, the emergence of large supermarket chains [ 75, 76, 78] may have also contributed to altered pricing and availability of milk and SSCBs.
The availability of engineered avGFP variants with altered color, where color refers to the absorbance and/or fluorescence emission spectral profiles, has been a boon to life science research.
Analysis of the role of the eEF1Bα protein capitalized on the availability of the K120R S121Δ I122Δ mutant form of the protein that altered or deleted residues involved in critical interactions with the nucleotide binding pocket of eEF1A [22].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com