Sentence examples for altered alternative from inspiring English sources

Expression of 60 CUG repeats altered alternative splicing of CG30084 and TnT transcripts although these repeats did not appreciably affect muscle morphology and did not accumulate in ribonuclear foci.

Immunoblot analysis was used to detect constitutive AOX production and altered alternative respiratory pathway capacity was determined using established methods [ 20, 45, 40, 64].

Ultimately, we identify NUDT21 as a novel candidate for intellectual disability and neuropsychiatric disease, and elucidate a mechanism of pathogenesis by MeCP2 dysregulation via altered alternative polyadenylation.

SAFB1 iCLIP tags were found in the NCAM1 gene and NCAM1 minigene experiments showed that SAFB1 knockdown altered alternative splicing and that mutation of the GAA, AAG and AGA motifs significantly decreased this regulation.

Therefore, depending on which start site is used to generate individual isoforms, or if any isoforms have altered alternative exon splicing, it is likely that the α-helical structures utilised in a single SR could be altered in different variants, leading to a change in strength or abolishment, of protein binding to a common SR.

Further studies to elucidate the underlying molecular mechanism for altered alternative splicing for the CAD gene in HCC are warranted.

However, cancers caused by mutations in SR protein binding sites may benefit from a molecule's ability to both induce mitotic arrest and alter alternative splicing, and there is growing evidence to suggest that altering the balance of SF2/ASF expression regulates malignant transformation via alternative splicing of Ron tyrosine kinase receptor and Rac1 GTPase [81].

They found that MALAT1 did not alter alternative splicing but rather actively regulated gene expression including a set of metastasis-associated genes.

Since B52 overexpression can alter alternative splicing (Fic et al. 2007; Gabut et al. 2007), it may modify the expression of mRNAs encoding regulators of myc transcription.

In Illinois, this change profoundly altered the alternative certification landscape.

Our results now make it clear that the function and impact of many constitutively expressed genes could be significantly altered by alternative splicing events during lymphocyte activation.