Proteins showing significantly altered abundance were selected for identification via mass spectrometry and bioinformatics analysis.
Many of those genes demonstrating altered abundance associated with the translational elongation pathway are ribosomal components.
Several studies suggest that an important mechanism for modulating inhibitory transmission is altered abundance of synaptic GABAA receptors.
Comparison of two ripening stages of peach revealed altered abundance of 53 proteins, among these, proteins involved in both primary and secondary metabolism, ethylene biosynthesis, and stress response.
Using these boundary conditions a total number of 168 and 153 proteins, respectively, showed a significantly altered abundance in mutant strains SAA012 and SAW041.
Overall, these data indicate that the positive effect of AMPK on Nrf2-mediated transcription in our system does not imply altered abundance or nuclear translocation of Nrf2.
While a number H2B species displayed altered abundance in the CLL patient samples, these species were all very low in abundance and are also highly modified (Table 1).
A candidate list for subsequent verification was compiled from proteins showing significantly altered abundance, potentially due to the presence of MIAC and HCA.
The current findings indicate altered abundance of specific genes may be involved in the differential phenotypic toxicities observed in male and female mice following exposure to TCDD.
Many "candidate" genes (i.e., Ggt6, Mmp12, Psat1, Rcan3 and Serpina7) showed altered abundance at only the later time-points examined (3 and/or 6 days post-exposure), likely indicating secondary responses to exposure.
Indeed many of the profiling candidates we identified as having altered abundance with age may be a result of changes in germline expression due to the massive increase in germline DNA copy number with age.
