Sentence examples for alterations with high from inspiring English sources

Translation of these discoveries into clinical applications requires the development of genomic tests that can reliably detect such somatic alterations with high sensitivity and specificity.

We used OPEN to construct 37 highly active ZFN pairs which induced targeted alterations with high efficiencies (1%–50%) at 11 different target sites located within three endogenous human genes (VEGF-A, HoxB13, and CFTR), an endogenous plant gene (tobacco SuRA), and a chromosomally integrated EGFP reporter gene.

Some loci showed both genetic and epigenetic alterations with high frequencies.

We therefore compared common CN alterations with high frequencies in rectal versus colon cancers.

Recently array-based CGH (A-CGH) on BAC and cDNA microarrays has been used to investigate the genomic alterations with high resolution [ 10- 14].

Recent advances in microarray technology made it possible to screen the genome for chromosomal imbalances (= loss of heterozygosity (LOH) and/or DNA copy number (CN) alterations) with high resolution [ 9- 13].

The overall genomic profile of ICC showed many alterations with higher rates for the deletions.

Moreover, a smaller deletion, exons 9 12 del, was identified in a Hispanic survey which is considered as Mexican founder BRCA1 alteration with high frequency (10 12%) [ 97].

These alterations associated with high PGF2α expression.

Although one of them exhibited strong chromosomal instability and alterations associated with high aggressiveness, CDD banding revealed the existence of a second, less rearranged and nearly diploid subclone.

Since it is likely that many alterations of low prevalence exist in human cancers, an individual tumour might still acquire several of these different alterations with a high probability, making low prevalence alterations a powerful driving force of the carcinogenic process.