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Importantly, when Cdc42 was acutely inactivated in supporting cells at a mature stage, no phenotypic alterations were seen, in contrast to acute inactivation during early postnatal development.
In general, more marked alterations were seen in Gpx1−/− as compared with WT mice, supporting the role of Gpx1 in cellular defense against oxidant stress to cope with aberrant gene expression.
The clonal nature of these alterations, and the fact that identical alterations were seen in more than one tumor, suggests a role for these mutant receptor proteins in tumorigenesis.
Pathological alterations were seen in the corresponding tissues of the control animals.
Typical apoptotic alterations were seen in HL-60 cells with surface blebs and nuclear fragmentation (Fig. 2C).
Our study now indicates that the phospholipid changes precede, rather than follow, the inflammatory process since similar lipid alterations were seen in mice where inflammation is partly halted.
Similar(26)
Three broad categories of DNA alterations are seen as possible with gene editing, and society will have to weigh them.
Coexistence of PIK3CA mutations and PTEN alterations was seen in 6.6% of CRC, suggesting that PI3K/AKT pathway can be activated by alterations in multiple genes.
Epigenetic alterations are seen in various cancers, and are currently used clinically as diagnostic markers [ 44].
Importantly, comparable FA alterations are seen in patients with psychiatric disorders.
Unexpectedly, the highest frequency of alterations was seen in IDHmut grade IV gliomas.
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